PAK6

Across TCGA pan-cancer cohorts, PAK6 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PAK6 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PAK6 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PAK6 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where PAK6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.153	0.798	.017	24	view →
PDAC	OS	Tertile	All	0.248	0.741	.016	12	view →
LUAD	DFS	Quartile	All	0.320	0.743	.011	8	view →
LSCC	DFS	Median	III,IV	0.894	0.419	.004	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PAK6–HNSC (OS)

Open the HNSC breakdown →