PAK6

Across TCGA patient cohorts, PAK6 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAK6-associated genes across cancer lineages are TFRC, Notch1, and P-Cadherin. Each is linked with PAK6 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAK6-to-partner and partner-to-PAK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by PAK6-low versus PAK6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK6→partner) and Y-score (partner→PAK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.522	+3.700	.004	.001	3	3
UCEC	Notch1 →	+0.173	+1.736	<.001	.007	3	2
UCEC	P-Cadherin →	-0.137	-2.807	.006	.002	3	2
UCEC	PCNA →	+0.273	+2.070	<.001	.001	3	2
UCEC	Rictor_pT1135 →	-0.110	-1.807	.001	.024	3	2
UCEC	Caspase-7-cleavedD198 →	+0.549	+1.604	.007	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

TFRC by PAK6 expression — UCEC

Explore this box plot interactively →