PAK6

Across TCGA cell cohorts, PAK6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,292 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible PAK6-associated GO terms across cancer lineages are Regulation of myoblast fusion, Cellular response to indole-3-methanol, and Response to sorbitol. Each is linked with PAK6 in more than 9 cancer types. Because this analysis shows association rather than direction, both PAK6-to-partner and partner-to-PAK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by PAK6-low versus PAK6-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK6→partner) and Y-score (partner→PAK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of myoblast fusion →	+0.125	+2.022	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Cellular response to indole-3-methanol →	+0.208	+2.036	.003	<.001	3	10
BREAST	Response to sorbitol →	+0.167	+1.696	<.001	.003	3	10
OVARY	Regulation of syncytium formation by plasma membrane fusion →	+0.127	+1.890	<.001	<.001	3	10
KIDNEY	Regulation of protein localization to nucleus →	+0.066	+0.586	.001	.003	3	10
OVARY	Negative regulation of syncytium formation by plasma membrane fusion →	+0.125	+1.940	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,292 associations by consensus.

Regulation of myoblast fusion by PAK6 expression — OVARY

Explore this box plot interactively →