PAK6

Across TCGA cell cohorts, PAK6 mutation is significantly associated with the RNA expression of many other genes, with 53 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PAK6-associated genes across cancer lineages are IQCF5, MC2R, and NANOS2. Each is linked with PAK6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAK6-to-partner and partner-to-PAK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by PAK6-low versus PAK6-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK6→partner) and Y-score (partner→PAK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.042	+4.357	<.001	.006	3	2
SOFT_TISSUE	MC2R →	+0.044	+4.392	<.001	.004	3	1
SOFT_TISSUE	NANOS2 →	+0.074	+3.865	<.001	.006	3	1
SOFT_TISSUE	BPIFA1 →	+0.246	+3.635	.001	.007	3	1
SOFT_TISSUE	MUC5AC →	+0.453	+4.076	.008	.008	3	1
SOFT_TISSUE	BPIFB2 →	+0.428	+3.635	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

IQCF5 by PAK6 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →