PAK5

Across TCGA cell cohorts, PAK5 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,065 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PAK5-associated GO terms across cancer lineages are Regulation of nucleotide-excision repair, Regulation of DNA repair, and Positive regulation of double-strand break repair. Each is linked with PAK5 in more than 5 cancer types. Because this analysis shows association rather than direction, both PAK5-to-partner and partner-to-PAK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nucleotide-excision repair grouped by PAK5-low versus PAK5-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK5→partner) and Y-score (partner→PAK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of nucleotide-excision repair →	+0.135	+1.533	<.001	<.001	3	6
LUNG_SCLC	Regulation of DNA repair →	+0.049	+0.959	<.001	<.001	3	6
LUNG_SCLC	Positive regulation of double-strand break repair →	+0.059	+0.797	.001	.006	3	6
OESOPHAGUS	Heart contraction →	-0.115	-0.096	.005	.006	3	5
KIDNEY	CDP-choline pathway →	-0.117	-0.030	.002	.008	3	5
BLOOD_Lymphoma	Regulation of chromosome organization →	+0.052	+0.060	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,065 associations by consensus.

Regulation of nucleotide-excision repair by PAK5 expression — LUNG_SCLC

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