PAK5

Across TCGA cell cohorts, PAK5 mutation is significantly associated with the RNA expression of many other genes, with 564 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAK5-associated genes across cancer lineages are OR11H1, DPH5, and MED18. Each is linked with PAK5 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAK5-to-partner and partner-to-PAK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H1 grouped by PAK5-low versus PAK5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK5→partner) and Y-score (partner→PAK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR11H1 →	+0.039	+3.464	<.001	.003	3	2
LARGE_INTESTINE	DPH5 →	+0.688	+3.364	<.001	.002	3	2
LARGE_INTESTINE	MED18 →	+0.643	+3.364	<.001	.002	3	2
LARGE_INTESTINE	GRSF1 →	+0.687	+3.082	<.001	.007	3	2
LARGE_INTESTINE	GSTCD →	+0.588	+3.234	.004	.004	3	2
LARGE_INTESTINE	GART →	+0.551	+3.364	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 564 associations by consensus.

OR11H1 by PAK5 expression — BLOOD_Leukemia

Explore this box plot interactively →