PAK3

Across TCGA pan-cancer cohorts, PAK3 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PAK3 data layer compared with 22 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PAK3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PAK3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ACC, UCEC, and COAD are the cancer types where PAK3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.248	0.831	<.001	22	view →
UCEC	DFS	Median	All	0.956	0.826	.013	22	view →
COAD	OS	Median	IV	0.045	0.659	<.001	19	view →
LIHC	DFS	Median	All	0.111	0.557	<.001	15	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PAK3–ACC (OS)

Open the ACC breakdown →