PAK3

Across TCGA pan-cancer cohorts, PAK3 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PAK3 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PAK3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PAK3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

PDAC and GBM are the cancer types where PAK3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.484	0.296	.003	22	view →
GBM	DFS	Quartile	All	0.908	0.602	<.001	5	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PAK3–PDAC (DFS)

Open the PDAC breakdown →