PAK3

Across TCGA patient cohorts, PAK3 protein abundance is significantly associated with the RNA expression of many other genes, with 8,052 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PAK3-associated genes across cancer lineages are LGALS1, PYGL, and CHGA. Each is linked with PAK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAK3-to-partner and partner-to-PAK3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PAK3 versus LGALS1 in PDAC, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK3→partner) and Y-score (partner→PAK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	LGALS1 →	-0.529	-0.464	.009	.005	3	2
PDAC	PYGL →	-0.895	-0.672	<.001	<.001	3	2
GBM	CHGA →	+1.784	+0.623	<.001	<.001	3	2
GBM	HIF1A →	-0.528	-0.458	<.001	.001	3	2
GBM	CCN4 →	-1.025	-0.407	.004	.001	3	2
PDAC	SYDE1 →	-0.437	-0.487	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,052 associations by consensus.

PAK3 vs LGALS1 — PDAC

Explore this scatter interactively →