PAK3

Across TCGA patient cohorts, PAK3 mutation is significantly associated with the RNA expression of many other genes, with 4,133 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAK3-associated genes across cancer lineages are RPP30, ANKRD20A3P, and MIR34B. Each is linked with PAK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAK3-to-partner and partner-to-PAK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPP30 grouped by PAK3-low versus PAK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK3→partner) and Y-score (partner→PAK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPP30 →	+0.328	+1.898	.003	.001	3	3
LIHC	ANKRD20A3P →	+0.024	+5.008	<.001	.004	3	2
ACC	MIR34B →	+0.424	+4.887	<.001	.009	3	2
LIHC	RN7SL149P →	+0.158	+6.032	<.001	<.001	3	2
SARC	MIR3667 →	+0.750	+5.224	<.001	.006	3	2
LIHC	MRPS15P1 →	+0.060	+4.415	.008	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,133 associations by consensus.

RPP30 by PAK3 expression — UCEC

Explore this box plot interactively →