PAK3

Across TCGA patient cohorts, PAK3 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAK3-associated genes across cancer lineages are eIF4E, Cyclin-B1, and eEF2. Each is linked with PAK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAK3-to-partner and partner-to-PAK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PAK3-low versus PAK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK3→partner) and Y-score (partner→PAK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.171	+2.713	.009	.003	3	3
UCEC	Cyclin-B1 →	+0.700	+2.502	<.001	.001	3	3
UCEC	eEF2 →	+0.332	+2.807	.003	.002	3	2
UCEC	MEK1 →	+0.382	+2.999	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.293	+1.594	.004	.021	3	2
UCEC	PCNA →	+0.253	+2.115	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

eIF4E by PAK3 expression — UCEC

Explore this box plot interactively →