PAK3

Across TCGA cell cohorts, PAK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,496 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PAK3-associated GO terms across cancer lineages are PML body organization, Negative regulation of cilium assembly, and Positive regulation of focal adhesion assembly. Each is linked with PAK3 in more than 7 cancer types. Because this analysis shows association rather than direction, both PAK3-to-partner and partner-to-PAK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PML body organization grouped by PAK3-low versus PAK3-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK3→partner) and Y-score (partner→PAK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PML body organization →	+0.192	+0.835	<.001	<.001	3	8
LUNG_SCLC	Negative regulation of cilium assembly →	+0.064	+1.623	.008	.003	3	8
URINARY_TRACT	Positive regulation of focal adhesion assembly →	+0.160	+0.828	<.001	.005	3	8
KIDNEY	Process utilizing autophagic mechanism →	+0.043	+0.861	.001	.002	3	8
KIDNEY	Autophagy →	+0.043	+0.861	.001	.002	3	8
LUNG_SCLC	Purine ribonucleotide metabolic process →	+0.062	+2.126	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,496 associations by consensus.

PML body organization by PAK3 expression — OVARY

Explore this box plot interactively →