PAK1IP1

Across TCGA pan-cancer cohorts, PAK1IP1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PAK1IP1 data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PAK1IP1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PAK1IP1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

HNSC, LSCC, and LUAD are the cancer types where PAK1IP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.134	1.000	.008	55	view →
LSCC	DFS	Median	II,III,IV	0.862	0.515	<.001	42	view →
LUAD	DFS	Median	III,IV	0.947	0.570	.002	19	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	9	view →
CCRCC	OS	Median	III,IV	0.485	1.000	.036	5	view →
UCEC	DFS	Median	All	1.000	0.937	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PAK1IP1–HNSC (OS)

Open the HNSC breakdown →