PAK1IP1

Across TCGA patient cohorts, PAK1IP1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAK1IP1-associated genes across cancer lineages are mTOR_pS2448, EGFR_pY1068, and JNK2. Each is linked with PAK1IP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAK1IP1-to-partner and partner-to-PAK1IP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by PAK1IP1-low versus PAK1IP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK1IP1→partner) and Y-score (partner→PAK1IP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.170	-2.321	.005	.006	3	2
UCEC	EGFR_pY1068 →	-0.233	-2.000	.024	.030	3	1
UCEC	JNK2 →	+0.173	+1.807	.035	.027	3	1
UCEC	MAPK_pT202_Y204 →	-0.481	-1.807	.013	.027	3	1
UCEC	MEK1 →	+0.459	+3.700	.002	.001	3	1
UCEC	MIG-6 →	+0.091	+1.820	.025	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

mTOR_pS2448 by PAK1IP1 expression — UCEC

Explore this box plot interactively →