PAK1

Across TCGA pan-cancer cohorts, PAK1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PAK1 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PAK1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PAK1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, CCRCC, and PDAC are the cancer types where PAK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.944	0.469	.003	42	view →
CCRCC	DFS	Median	II,III,IV	0.887	0.283	.012	17	view →
PDAC	OS	Tertile	All	0.538	0.229	.001	14	view →
LSCC	OS	Median	II,III,IV	1.000	0.884	.022	13	view →
HNSC	DFS	Median	All	0.698	1.000	.020	10	view →
LUAD	OS	Tertile	II,III,IV	0.871	0.333	.028	7	view →
GBM	OS	Quartile	All	0.307	0.631	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PAK1–UCEC (DFS)

Open the UCEC breakdown →