PAK1

Across TCGA patient cohorts, PAK1 mutation is significantly associated with the RNA expression of many other genes, with 2,827 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAK1-associated genes across cancer lineages are MTCYBP10, RPL36P1, and TRBV21OR9-2. Each is linked with PAK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAK1-to-partner and partner-to-PAK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCYBP10 grouped by PAK1-low versus PAK1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK1→partner) and Y-score (partner→PAK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MTCYBP10 →	+0.048	+5.252	<.001	.002	3	3
LUAD	RPL36P1 →	+0.238	+7.930	<.001	.008	3	2
CESC	TRBV21OR9-2 →	+0.091	+5.252	<.001	.002	3	2
CESC	LINC01751 →	+0.018	+4.384	<.001	.008	3	2
STAD	ACTR3BP6 →	+0.037	+5.187	<.001	.007	3	2
SKCM	RNU6-264P →	+0.388	+5.362	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,827 associations by consensus.

MTCYBP10 by PAK1 expression — CESC

Explore this box plot interactively →