PAK1

Across TCGA patient cohorts, PAK1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAK1-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and EGFR. Each is linked with PAK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAK1-to-partner and partner-to-PAK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PAK1-low versus PAK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK1→partner) and Y-score (partner→PAK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.551	+1.894	.011	.030	3	2
UCEC	14-3-3_beta →	-0.099	-1.973	.007	.029	3	1
UCEC	EGFR →	-0.196	-2.700	<.001	.006	3	1
UCEC	eIF4E →	+0.247	+2.247	.001	.001	2	2
UCEC	A-Raf_pS299 →	-0.145	-2.115	<.001	.017	3	1
UCEC	ACC_pS79 →	+0.424	+2.247	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Caspase-7-cleavedD198 by PAK1 expression — UCEC

Explore this box plot interactively →