PAK1

Across TCGA cell cohorts, PAK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,259 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PAK1-associated GO terms across cancer lineages are Protein localization to cytoplasmic stress granule, Positive regulation of intracellular estrogen receptor signaling pathway, and Positive regulation of intracellular steroid hormone receptor signaling pathway. Each is linked with PAK1 in more than 15 cancer types. Because this analysis shows association rather than direction, both PAK1-to-partner and partner-to-PAK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to cytoplasmic stress granule grouped by PAK1-low versus PAK1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK1→partner) and Y-score (partner→PAK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Protein localization to cytoplasmic stress granule →	+0.173	+1.194	<.001	<.001	3	16
LIVER	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.188	+1.566	.003	.001	1	15
OVARY	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.139	+1.245	<.001	.001	3	12
BONE	Positive regulation of microtubule nucleation →	+0.180	+1.291	<.001	<.001	3	12
KIDNEY	Negative regulation of cardiac muscle hypertrophy →	+0.110	+0.800	.001	.002	3	11
BLOOD_Myeloma	Hepatocyte growth factor receptor signaling pathway →	+0.224	+2.175	.002	.001	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,259 associations by consensus.

Protein localization to cytoplasmic stress granule by PAK1 expression — LUNG_SCLC

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