PAK1

Across TCGA cell cohorts, PAK1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAK1-associated genes across cancer lineages are IAPP, H1-1, and SCN2A. Each is linked with PAK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAK1-to-partner and partner-to-PAK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IAPP grouped by PAK1-low versus PAK1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK1→partner) and Y-score (partner→PAK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IAPP →	+0.409	+3.491	<.001	<.001	3	1
LARGE_INTESTINE	H1-1 →	+0.065	+2.791	<.001	.005	3	1
LARGE_INTESTINE	SCN2A →	+0.642	+3.881	<.001	<.001	3	1
LARGE_INTESTINE	TRH →	+0.068	+3.830	.003	.003	3	1
LARGE_INTESTINE	ABCD2 →	+0.108	+3.639	<.001	<.001	3	1
LUNG_SCLC	OR5AU1 →	+0.024	+4.269	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

IAPP by PAK1 expression — LARGE_INTESTINE

Explore this box plot interactively →