PAIP2B

Across TCGA patient cohorts, PAIP2B mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAIP2B-associated genes across cancer lineages are eIF4E, FOXO3a_pS318_S321, and Rab25. Each is linked with PAIP2B in more than 1 cancer types. Because this analysis shows association rather than direction, both PAIP2B-to-partner and partner-to-PAIP2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PAIP2B-low versus PAIP2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAIP2B→partner) and Y-score (partner→PAIP2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.277	+3.169	.016	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.154	-3.169	.025	.020	3	1
UCEC	Rab25 →	-0.574	-3.000	.001	.036	3	1
UCEC	TFRC →	+0.912	+3.169	.001	.020	3	1
UCEC	C-Raf →	+0.273	+3.169	<.001	.019	3	1
UCEC	EGFR_pY1068 →	-0.328	-3.169	.017	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

eIF4E by PAIP2B expression — UCEC

Explore this box plot interactively →