PAIP2

Across TCGA patient cohorts, PAIP2 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAIP2-associated genes across cancer lineages are RNU6-497P, BNIP3P19, and IL17A. Each is linked with PAIP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAIP2-to-partner and partner-to-PAIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-497P grouped by PAIP2-low versus PAIP2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAIP2→partner) and Y-score (partner→PAIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-497P →	+0.392	+5.097	<.001	.008	3	1
SKCM	BNIP3P19 →	+0.101	+5.159	<.001	.007	3	1
UCEC	IL17A →	+0.200	+4.294	.006	<.001	3	1
UCEC	MIR548D2 →	+0.657	+4.279	<.001	.001	3	1
UCEC	MIR4535 →	+0.559	+4.555	<.001	.005	3	1
UCEC	NUTF2P8 →	+0.225	+3.567	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

RNU6-497P by PAIP2 expression — SKCM

Explore this box plot interactively →