PAIP1

Across TCGA patient cohorts, PAIP1 mutation is significantly associated with the RNA expression of many other genes, with 2,022 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAIP1-associated genes across cancer lineages are RNA5SP172, LINC01639, and BRWD1P2. Each is linked with PAIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAIP1-to-partner and partner-to-PAIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP172 grouped by PAIP1-low versus PAIP1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAIP1→partner) and Y-score (partner→PAIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP172 →	+0.335	+3.754	<.001	.008	3	2
LUAD	LINC01639 →	+0.398	+3.787	<.001	.007	3	2
LUAD	BRWD1P2 →	+0.450	+4.113	<.001	.005	3	2
UCEC	PELO →	+0.418	+2.502	.004	.009	3	2
UCEC	UTP15 →	+0.451	+2.323	<.001	<.001	3	2
UCEC	UBAP1 →	+0.544	+2.736	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,022 associations by consensus.

RNA5SP172 by PAIP1 expression — LUAD

Explore this box plot interactively →