PAIP1

Across TCGA patient cohorts, PAIP1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAIP1-associated genes across cancer lineages are eIF4E, Caspase-7-cleavedD198, and eEF2. Each is linked with PAIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAIP1-to-partner and partner-to-PAIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PAIP1-low versus PAIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAIP1→partner) and Y-score (partner→PAIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.190	+1.906	.025	.016	3	2
UCEC	Caspase-7-cleavedD198 →	+0.500	+2.189	.036	.034	3	2
UCEC	eEF2 →	+0.381	+1.906	.008	.016	3	1
UCEC	Fibronectin →	-0.293	-2.105	.027	.017	3	1
UCEC	JNK2 →	+0.271	+1.906	<.001	.016	3	1
UCEC	Ku80 →	+0.232	+2.594	.014	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

eIF4E by PAIP1 expression — UCEC

Explore this box plot interactively →