PAIP1

Across TCGA cell cohorts, PAIP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,007 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PAIP1-associated GO terms across cancer lineages are Establishment of mitotic sister chromatid cohesion, Positive regulation of cytoplasmic translation, and Replication-born double-strand break repair via sister chromatid exchange. Each is linked with PAIP1 in more than 16 cancer types. Because this analysis shows association rather than direction, both PAIP1-to-partner and partner-to-PAIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of mitotic sister chromatid cohesion grouped by PAIP1-low versus PAIP1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAIP1→partner) and Y-score (partner→PAIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Establishment of mitotic sister chromatid cohesion →	+0.158	+0.914	.001	.001	3	17
STOMACH	Positive regulation of cytoplasmic translation →	+0.118	+0.674	<.001	<.001	3	16
SKIN	Replication-born double-strand break repair via sister chromatid exchange →	+0.179	+0.762	<.001	<.001	3	14
LUNG_SCLC	Negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.158	+1.266	<.001	.001	3	13
STOMACH	Response to rapamycin →	+0.144	+0.631	.002	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.140	+1.070	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,007 associations by consensus.

Establishment of mitotic sister chromatid cohesion by PAIP1 expression — OESOPHAGUS

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