PAIP1

Across TCGA cell cohorts, PAIP1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAIP1-associated genes across cancer lineages are TMEM244, INSM2, and WFDC12. Each is linked with PAIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAIP1-to-partner and partner-to-PAIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM244 grouped by PAIP1-low versus PAIP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAIP1→partner) and Y-score (partner→PAIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMEM244 →	+0.269	+3.551	<.001	.009	3	2
BLOOD_Leukemia	INSM2 →	+0.157	+3.769	.003	.008	3	1
BLOOD_Leukemia	WFDC12 →	+0.198	+3.874	<.001	.005	3	1
BLOOD_Leukemia	KRT38 →	+0.012	+3.705	<.001	.007	3	1
BLOOD_Leukemia	DEFB4A →	+0.096	+4.269	.001	.002	3	1
BLOOD_Leukemia	GUCA2A →	+0.031	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

TMEM244 by PAIP1 expression — BLOOD_Leukemia

Explore this box plot interactively →