PAH

Across TCGA patient cohorts, PAH mutation is significantly associated with the RNA expression of many other genes, with 1,369 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAH-associated genes across cancer lineages are LINC02641, OR9Q2, and OR7E105P. Each is linked with PAH in more than 2 cancer types. Because this analysis shows association rather than direction, both PAH-to-partner and partner-to-PAH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02641 grouped by PAH-low versus PAH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAH→partner) and Y-score (partner→PAH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC02641 →	+0.209	+2.327	<.001	<.001	3	3
READ	OR9Q2 →	+0.032	+4.681	<.001	.003	3	2
READ	OR7E105P →	+0.049	+4.039	<.001	.002	3	2
SKCM	LINC01808 →	+0.012	+2.946	<.001	.005	3	2
SKCM	TOMM22P6 →	+0.024	+2.946	<.001	.005	3	2
SKCM	RPL39P28 →	+0.081	+2.161	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,369 associations by consensus.

LINC02641 by PAH expression — UCEC

Explore this box plot interactively →