PAH

Across TCGA cell cohorts, PAH RNA expression is significantly associated with the go_rna of many other GO terms, with 1,616 significant associations in total. LIVER shows the largest number of these associations.

The most reproducible PAH-associated GO terms across cancer lineages are Geranylgeranyl diphosphate metabolic process, Alcohol biosynthetic process, and Positive regulation of ERBB signaling pathway. Each is linked with PAH in more than 5 cancer types. Because this analysis shows association rather than direction, both PAH-to-partner and partner-to-PAH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Geranylgeranyl diphosphate metabolic process grouped by PAH-low versus PAH-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAH→partner) and Y-score (partner→PAH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Geranylgeranyl diphosphate metabolic process →	+0.102	+0.469	.001	.003	2	6
LUNG_SCLC	Alcohol biosynthetic process →	+0.122	+2.236	<.001	<.001	3	5
BREAST	Positive regulation of ERBB signaling pathway →	-0.089	-0.442	<.001	.009	3	4
LUNG_SCLC	Regulation of macroautophagy →	+0.056	+1.690	<.001	<.001	3	4
OESOPHAGUS	Positive regulation of protein-containing complex assembly →	+0.038	+0.146	.002	.005	3	4
LUNG_SCLC	Negative regulation of iron ion transport →	+0.072	+1.578	<.001	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,616 associations by consensus.

Geranylgeranyl diphosphate metabolic process by PAH expression — BREAST

Explore this box plot interactively →