PAGE5

Across TCGA pan-cancer cohorts, PAGE5 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PAGE5 data layer compared with 26 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher PAGE5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PAGE5 expression acts as an unfavorable survival marker.

READ, SCLC, and SARC are the cancer types where PAGE5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	II,III,IV	0.054	0.934	<.001	24	view →
SCLC	OS	Median	All	0.082	0.708	<.001	12	view →
SARC	DFS	Median	All	0.098	0.611	.006	6	view →
COAD	DFS	Median	All	0.223	0.691	.011	6	view →
SKCM	DFS	Median	II,III,IV	0.139	0.712	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PAGE5–READ (OS)

Open the READ breakdown →