PAGE4

Across TCGA patient cohorts, PAGE4 mutation is significantly associated with the RNA expression of many other genes, with 103 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAGE4-associated genes across cancer lineages are CTBP2P9, RNA5SP461, and RNA5SP410. Each is linked with PAGE4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAGE4-to-partner and partner-to-PAGE4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTBP2P9 grouped by PAGE4-low versus PAGE4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAGE4→partner) and Y-score (partner→PAGE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CTBP2P9 →	+0.080	+6.080	<.001	.002	3	2
HNSC	RNA5SP461 →	+0.247	+7.954	<.001	.008	3	2
UCEC	RNA5SP410 →	+0.974	+2.789	<.001	.004	3	2
SKCM	RNU6-1169P →	+0.405	+5.362	<.001	.005	3	2
BLCA	CYP3A54P →	+0.342	+7.640	<.001	.009	3	1
BLCA	MIR548AV →	+0.397	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 103 associations by consensus.

CTBP2P9 by PAGE4 expression — SKCM

Explore this box plot interactively →