PAGE4

Across TCGA patient cohorts, PAGE4 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAGE4-associated genes across cancer lineages are EGFR_pY1068, EGFR, and MSH2. Each is linked with PAGE4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAGE4-to-partner and partner-to-PAGE4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PAGE4-low versus PAGE4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAGE4→partner) and Y-score (partner→PAGE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.291	-3.169	.034	.020	3	1
UCEC	EGFR →	-0.174	-3.169	.047	.020	3	1
UCEC	MSH2 →	-0.361	-3.169	.004	.020	3	1
UCEC	p62 Lck ligand →	+0.589	+3.169	<.001	.020	3	1
UCEC	TIGAR →	+0.174	+3.196	.038	.010	3	1
UCEC	Rab25 →	-0.804	-3.169	<.001	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

EGFR_pY1068 by PAGE4 expression — UCEC

Explore this box plot interactively →