PAGE2B

Across TCGA pan-cancer cohorts, PAGE2B RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PAGE2B data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PAGE2B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PAGE2B expression acts as an unfavorable survival marker, although some lineages such as SKCM and CESC show a favorable association.

KIRC, COAD, and UCEC are the cancer types where PAGE2B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.526	0.725	<.001	114	view →
COAD	OS	Quartile	III,IV	0.242	0.651	<.001	75	view →
UCEC	OS	Quartile	All	0.879	0.948	.004	62	view →
MESO	DFS	Median	All	0.275	0.442	.003	59	view →
DLBC	DFS	Quartile	All	0.563	0.971	.004	43	view →
SKCM	OS	Tertile	All	0.424	0.281	.001	40	view →
LIHC	DFS	Tertile	All	0.437	0.601	<.001	35	view →
SCLC	DFS	Tertile	II,III,IV	0.168	0.636	.004	30	view →
PRAD	DFS	Median	All	0.834	0.929	<.001	20	view →
CESC	OS	Quartile	II,III,IV	0.856	0.607	.021	14	view →
LUSC	OS	Quartile	II,III,IV	0.481	0.892	<.001	13	view →
ESCA	DFS	Median	IV	0.213	0.626	.026	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PAGE2B–KIRC (OS)

Open the KIRC breakdown →