PAG1

Across TCGA pan-cancer cohorts, PAG1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PAG1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PAG1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PAG1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where PAG1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	II,III,IV	0.533	0.958	.004	32	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	24	view →
HNSC	OS	Median	III,IV	1.000	0.946	.037	8	view →
GBM	DFS	Tertile	All	0.231	0.521	.014	8	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	8	view →
LSCC	DFS	Tertile	II,III,IV	0.491	0.836	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PAG1–CCRCC (OS)

Open the CCRCC breakdown →