PAG1

Across TCGA patient cohorts, PAG1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,939 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PAG1-associated genes across cancer lineages are ARHGAP25, CEACAM21, and CASP5. Each is linked with PAG1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PAG1-to-partner and partner-to-PAG1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PAG1 versus ARHGAP25 in BRCA, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAG1→partner) and Y-score (partner→PAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGAP25 →	+0.752	+0.510	<.001	<.001	3	5
LSCC	CEACAM21 →	+0.724	+0.369	<.001	<.001	3	5
HNSC	CASP5 →	+1.186	+0.516	<.001	<.001	3	5
LSCC	TRBV6-1 →	+0.755	+0.292	<.001	<.001	3	5
BRCA	CD38 →	+1.241	+0.545	<.001	<.001	3	5
LSCC	JAK3 →	+0.863	+0.379	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,939 associations by consensus.

PAG1 vs ARHGAP25 — BRCA

Explore this scatter interactively →