PAG1

Across TCGA patient cohorts, PAG1 mutation is significantly associated with the RNA expression of many other genes, with 5,450 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAG1-associated genes across cancer lineages are SNORD116-22, TRAJ12, and IGHD5-12. Each is linked with PAG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAG1-to-partner and partner-to-PAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD116-22 grouped by PAG1-low versus PAG1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAG1→partner) and Y-score (partner→PAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	SNORD116-22 →	+0.631	+6.479	<.001	.001	3	2
CESC	TRAJ12 →	+0.677	+4.193	<.001	.009	3	2
READ	IGHD5-12 →	+1.287	+4.421	<.001	.009	3	2
UCEC	SNX3P1Y →	+0.056	+3.620	<.001	.009	3	2
HNSC	RNU6-517P →	+0.392	+5.124	<.001	.008	3	2
CESC	FAM197Y9 →	+0.011	+5.144	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,450 associations by consensus.

SNORD116-22 by PAG1 expression — LIHC

Explore this box plot interactively →