PAG1

Across TCGA patient cohorts, PAG1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAG1-associated genes across cancer lineages are Notch1, ASNS, and Bak. Each is linked with PAG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAG1-to-partner and partner-to-PAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by PAG1-low versus PAG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAG1→partner) and Y-score (partner→PAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.205	+2.916	<.001	<.001	3	2
UCEC	ASNS →	+0.405	+2.000	.001	.029	3	2
UCEC	Bak →	+0.224	+1.807	.010	.025	3	2
UCEC	Caspase-7-cleavedD198 →	+0.506	+1.604	.014	.021	3	2
UCEC	C-Raf →	+0.174	+1.678	<.001	.021	3	2
UCEC	EGFR_pY1068 →	-0.262	-2.070	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Notch1 by PAG1 expression — UCEC

Explore this box plot interactively →