PAG1

Across TCGA cell cohorts, PAG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,045 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PAG1-associated GO terms across cancer lineages are Positive regulation of fertilization, Symbiont-mediated disruption of host cellular anatomical structure, and Symbiont-mediated disruption of host anatomical structure. Each is linked with PAG1 in more than 8 cancer types. Because this analysis shows association rather than direction, both PAG1-to-partner and partner-to-PAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of fertilization grouped by PAG1-low versus PAG1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAG1→partner) and Y-score (partner→PAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Positive regulation of fertilization →	+1.089	+0.911	<.001	.009	2	9
UPPER_AERODIGESTIVE_TRACT	Symbiont-mediated disruption of host cellular anatomical structure →	+0.091	+0.710	.004	.005	2	8
UPPER_AERODIGESTIVE_TRACT	Symbiont-mediated disruption of host anatomical structure →	+0.091	+0.710	.004	.005	2	8
BLOOD_Lymphoma	Lactam metabolic process →	+1.220	+1.243	<.001	<.001	3	7
BREAST	Positive regulation of focal adhesion assembly →	+0.103	+0.676	.005	.005	2	8
OESOPHAGUS	Lysosomal transport →	+0.044	+0.841	.004	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,045 associations by consensus.

Positive regulation of fertilization by PAG1 expression — OVARY

Explore this box plot interactively →