PAG1

Across TCGA cell cohorts, PAG1 mutation is significantly associated with the RNA expression of many other genes, with 86 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible PAG1-associated genes across cancer lineages are KRTAP5-3, INS, and LGALS13. Each is linked with PAG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAG1-to-partner and partner-to-PAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP5-3 grouped by PAG1-low versus PAG1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAG1→partner) and Y-score (partner→PAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	KRTAP5-3 →	+0.076	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	INS →	+0.120	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	LGALS13 →	+0.099	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	OR7A10 →	+0.063	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	TAAR5 →	+0.093	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	ZIM3 →	+0.043	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

KRTAP5-3 by PAG1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →