PAFAH2

Across TCGA patient cohorts, PAFAH2 mutation is significantly associated with the RNA expression of many other genes, with 2,234 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAFAH2-associated genes across cancer lineages are RNU6-91P, CIDECP1, and NELFB. Each is linked with PAFAH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAFAH2-to-partner and partner-to-PAFAH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-91P grouped by PAFAH2-low versus PAFAH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAFAH2→partner) and Y-score (partner→PAFAH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-91P →	+0.363	+2.232	<.001	.007	3	2
UCEC	CIDECP1 →	+0.440	+3.823	<.001	<.001	3	2
UCEC	NELFB →	+0.441	+3.753	.005	<.001	3	2
UCEC	PRC1 →	+0.785	+3.087	.001	<.001	3	2
UCEC	RNU6-353P →	+0.707	+2.249	<.001	.001	3	2
UCEC	IGHD3-22 →	+1.684	+2.662	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,234 associations by consensus.

RNU6-91P by PAFAH2 expression — UCEC

Explore this box plot interactively →