PAFAH2

Across TCGA patient cohorts, PAFAH2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAFAH2-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and eIF4E. Each is linked with PAFAH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAFAH2-to-partner and partner-to-PAFAH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PAFAH2-low versus PAFAH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAFAH2→partner) and Y-score (partner→PAFAH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.102	-3.143	.013	.018	3	1
UCEC	EGFR_pY1068 →	-0.218	-2.321	.035	.034	3	1
UCEC	eIF4E →	+0.197	+3.183	.024	.009	3	1
UCEC	eIF4G →	+0.276	+3.169	.031	.018	3	1
UCEC	A-Raf_pS299 →	-0.149	-2.459	.002	.019	3	1
UCEC	FoxM1 →	+0.288	+2.331	.006	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

14-3-3_beta by PAFAH2 expression — UCEC

Explore this box plot interactively →