PAFAH1B3

Across TCGA pan-cancer cohorts, PAFAH1B3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PAFAH1B3 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PAFAH1B3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PAFAH1B3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where PAFAH1B3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	IV	0.830	0.198	.024	18	view →
HNSC	OS	Median	All	0.484	1.000	.038	6	view →
LSCC	DFS	Quartile	All	1.000	0.860	.019	4	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	4	view →
UCEC	OS	Quartile	All	0.888	1.000	.047	2	view →
GBM	DFS	Median	All	0.257	0.464	.032	2	view →
LUAD	DFS	Quartile	All	0.490	0.768	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PAFAH1B3–CCRCC (OS)

Open the CCRCC breakdown →