PAFAH1B1

Across TCGA pan-cancer cohorts, PAFAH1B1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PAFAH1B1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PAFAH1B1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PAFAH1B1 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and LSCC are the cancer types where PAFAH1B1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PAFAH1B1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.497	<.001	11	view →
LUAD	Male	III,IV	−0.317	<.001	9	view →
LSCC	Female	All	−0.318	<.001	8	view →
PDAC	Female	All	−0.197	<.001	6	view →
CCRCC	Male	II,III,IV	+0.130	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PAFAH1B1–COAD

Open the COAD breakdown →