PAF1

Across TCGA patient cohorts, PAF1 protein abundance is significantly associated with the RNA expression of many other genes, with 17,036 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PAF1-associated genes across cancer lineages are LIN9, TIPIN, and VRK1. Each is linked with PAF1 in more than 8 cancer types. Because this analysis shows association rather than direction, both PAF1-to-partner and partner-to-PAF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PAF1 versus LIN9 in GBM, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAF1→partner) and Y-score (partner→PAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LIN9 →	+0.703	+0.356	<.001	<.001	3	9
COAD	TIPIN →	+0.818	+0.311	<.001	<.001	3	9
HNSC	VRK1 →	+1.137	+0.205	<.001	<.001	3	8
GBM	HELLS →	+1.105	+0.401	<.001	<.001	3	8
HNSC	BRCA1 →	+1.029	+0.299	<.001	<.001	3	8
LSCC	TMPO →	+0.655	+0.250	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,036 associations by consensus.

PAF1 vs LIN9 — GBM

Explore this scatter interactively →