PAF1

Across TCGA cell cohorts, PAF1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAF1-associated genes across cancer lineages are KRTAP19-3, SCGB2A1, and CPLX4. Each is linked with PAF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAF1-to-partner and partner-to-PAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP19-3 grouped by PAF1-low versus PAF1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAF1→partner) and Y-score (partner→PAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KRTAP19-3 →	+0.194	+5.228	<.001	.005	3	1
LARGE_INTESTINE	SCGB2A1 →	+0.536	+3.392	<.001	.006	3	1
LARGE_INTESTINE	CPLX4 →	+0.030	+3.222	<.001	.002	3	1
LARGE_INTESTINE	ADH1B →	+0.053	+2.989	<.001	.003	3	1
LARGE_INTESTINE	IQCF6 →	+0.162	+2.882	.001	.005	3	1
BLOOD_Leukemia	MMP27 →	+0.019	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

KRTAP19-3 by PAF1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →