PAEP

Across TCGA patient cohorts, PAEP protein abundance is significantly associated with the RNA expression of many other genes, with 3,355 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PAEP-associated genes across cancer lineages are RSPH14, SYNGR1, and CHRDL1. Each is linked with PAEP in more than 1 cancer types. Because this analysis shows association rather than direction, both PAEP-to-partner and partner-to-PAEP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PAEP versus RSPH14 in UCEC, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAEP→partner) and Y-score (partner→PAEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RSPH14 →	-0.641	-1.084	<.001	.005	3	2
PDAC	SYNGR1 →	-0.709	-1.665	.002	.004	3	2
PDAC	CHRDL1 →	-1.654	-1.316	.003	.008	3	2
PDAC	GIMAP2 →	-0.597	-1.845	.008	.003	3	2
LSCC	IGSF11 →	-1.293	-0.966	<.001	.008	3	2
PDAC	GATM →	-1.703	-1.457	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,355 associations by consensus.

PAEP vs RSPH14 — UCEC

Explore this scatter interactively →