PAEP

Across TCGA patient cohorts, PAEP mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAEP-associated genes across cancer lineages are JNK2, Ku80, and MEK1. Each is linked with PAEP in more than 1 cancer types. Because this analysis shows association rather than direction, both PAEP-to-partner and partner-to-PAEP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by PAEP-low versus PAEP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAEP→partner) and Y-score (partner→PAEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.336	+2.817	.001	.036	3	1
UCEC	Ku80 →	+0.276	+3.335	.025	.005	3	1
UCEC	MEK1 →	+0.510	+3.321	.007	.010	3	1
UCEC	Notch1 →	+0.192	+2.820	.009	.035	3	1
UCEC	Caspase-8 →	-0.317	-3.000	.016	.036	2	1
UCEC	Di-Ras3 →	-0.205	-3.321	.008	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

JNK2 by PAEP expression — UCEC

Explore this box plot interactively →