PAEP

Across TCGA cell cohorts, PAEP RNA expression is significantly associated with the go_rna of many other GO terms, with 1,442 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PAEP-associated GO terms across cancer lineages are Regulation of sperm capacitation, Negative regulation of leukocyte activation, and Epidermis development. Each is linked with PAEP in more than 12 cancer types. Because this analysis shows association rather than direction, both PAEP-to-partner and partner-to-PAEP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of sperm capacitation grouped by PAEP-low versus PAEP-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PAEP→partner) and Y-score (partner→PAEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of sperm capacitation →	+1.279	+2.587	<.001	<.001	3	13
PANCREAS	Negative regulation of leukocyte activation →	+0.080	+1.282	<.001	.003	3	5
LARGE_INTESTINE	Epidermis development →	+0.059	+0.301	.001	.006	3	5
OVARY	Regulation of tolerance induction dependent upon immune response →	+0.888	+0.755	.007	.007	3	5
SKIN	Positive regulation of podosome assembly →	-1.517	-3.223	<.001	<.001	3	4
PANCREAS	Viral gene expression →	+0.091	+1.261	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,442 associations by consensus.

Regulation of sperm capacitation by PAEP expression — SKIN

Explore this box plot interactively →