PADI6

Across TCGA patient cohorts, PADI6 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PADI6-associated genes across cancer lineages are AMPK_pT172, Rictor_pT1135, and TAZ. Each is linked with PADI6 in more than 2 cancer types. Because this analysis shows association rather than direction, both PADI6-to-partner and partner-to-PADI6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AMPK_pT172 grouped by PADI6-low versus PADI6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PADI6→partner) and Y-score (partner→PADI6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	AMPK_pT172 →	+0.432	+2.000	.003	.031	3	2
SKCM	Rictor_pT1135 →	-0.140	-1.982	.042	.031	3	2
SKCM	TAZ →	+0.188	+3.182	.008	.009	3	2
SKCM	ASNS →	+0.742	+3.321	<.001	.009	2	3
SKCM	E-Cadherin →	-1.059	-3.169	.006	.018	3	2
UCEC	NDRG1_pT346 →	-0.433	-1.584	.014	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

AMPK_pT172 by PADI6 expression — SKCM

Explore this box plot interactively →