PADI3

Across TCGA cell cohorts, PADI3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,448 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PADI3-associated GO terms across cancer lineages are Positive regulation of protein import into nucleus, Chaperone-mediated autophagy, and Negative regulation of release of cytochrome c from mitochondria. Each is linked with PADI3 in more than 8 cancer types. Because this analysis shows association rather than direction, both PADI3-to-partner and partner-to-PADI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein import into nucleus grouped by PADI3-low versus PADI3-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PADI3→partner) and Y-score (partner→PADI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Positive regulation of protein import into nucleus →	+0.172	+4.074	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Chaperone-mediated autophagy →	+0.117	+2.209	.003	.001	2	9
URINARY_TRACT	Negative regulation of release of cytochrome c from mitochondria →	+0.097	+2.166	.001	.002	3	8
URINARY_TRACT	Regulation of protein import into nucleus →	+0.120	+2.892	.001	.007	3	8
LIVER	Cellular response to corticotropin-releasing hormone stimulus →	-1.463	-2.227	<.001	.002	3	7
STOMACH	Regulation of mitochondrion organization →	+0.075	+0.865	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,448 associations by consensus.

Positive regulation of protein import into nucleus by PADI3 expression — URINARY_TRACT

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