PADI3

Across TCGA cell cohorts, PADI3 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PADI3-associated genes across cancer lineages are CCL16, HRH3, and IFNG. Each is linked with PADI3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PADI3-to-partner and partner-to-PADI3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL16 grouped by PADI3-low versus PADI3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PADI3→partner) and Y-score (partner→PADI3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CCL16 →	+0.018	+4.357	<.001	.004	3	1
SKIN	HRH3 →	+0.039	+3.836	.001	.003	3	1
SKIN	IFNG →	+0.011	+3.700	<.001	.009	3	1
SKIN	SERPINA12 →	+0.028	+3.242	<.001	.003	3	1
SKIN	SOX14 →	+0.006	+3.562	<.001	.002	3	1
SKIN	GSX2 →	+0.045	+3.103	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

CCL16 by PADI3 expression — CNS

Explore this box plot interactively →