PADI2

Across TCGA cell cohorts, PADI2 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible PADI2-associated genes across cancer lineages are FTMT, LUZP4, and CLEC4M. Each is linked with PADI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PADI2-to-partner and partner-to-PADI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FTMT grouped by PADI2-low versus PADI2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PADI2→partner) and Y-score (partner→PADI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FTMT →	+0.065	+4.977	<.001	.002	3	1
STOMACH	LUZP4 →	+0.009	+3.432	<.001	.008	3	1
STOMACH	CLEC4M →	+0.100	+4.044	.003	.003	3	1
STOMACH	GYS2 →	+0.069	+3.432	.003	.008	3	1
STOMACH	ADGRG4 →	+0.005	+3.794	<.001	.003	3	1
STOMACH	AHSP →	+0.155	+3.432	.007	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

FTMT by PADI2 expression — SOFT_TISSUE

Explore this box plot interactively →